CRS Offers FOUR Educational Workshops in Copenhagen

The CRS Educational Workshop Review Committee and Board of Directors are pleased to announce the selection of the educational workshops for Copenhagen has been completed. You will surely find the educational offering that fits your needs. Registration for these educational workshops will open soon.

Saturday, July 18, 2009

Educational Workshop 1: RNA Interference Biology and Therapeutics;chaired by Ken Howard, Interdisciplinary Nanoscience Center (iNANO) at the University of Aarhus, Denmark; and Jørgen Kjems, Interdisciplinary Nanoscience Center (iNANO) at the University of Aarhus, Denmark
Attendees will gain knowledge of RNA interference from the cellular mechanisms to siRNA design right through to therapeutic applications. By understanding the basics of siRNA biology, an appreciation of its importance in cellular regulation and a clear idea of the rational and design behind RNAi-based therapies will be gained by the attendees.

• Pharmaceutical Development of Dicer-substrate siRNAs, Mark Behlke, IDT, U.S.A.
• RNAi as Antiviral Therapy: The HIV-1 Case, Ben Berkhout, University of Amsterdam, The Netherlands
• Developing siRNA as Therapeuticsi, Tony de Fougerolles, Alnylam Pharmaceuticals Inc., U.S.A.
• RNAi Therapeutic Silencing in Disease Models, Ken Howard, iNANO, University of Aarhus, Denmark
• The Biology of siRNA Processing, Jørgen Kjems, iNANO, University of Aarhus, Denmark
• Intracellular Delivery Considerations for RNAi Therapeutics, David Oupicky, Wayne State University, U.S.A.
• Targeted siRNA Delivery, Gert Storm, University of Utrecht, The Netherlands
• Functional Delivery of RNAi Therapeutics, Hans-Peter Vornlocher, Roche Kulmbach GmbH, Germany

Saturday, July 18-Sunday, July 19, 2009

Educational Workshop 2: Imaging in Drug Development; chaired by Ole Hjelstuen, University of Tromsö/GE Healthcare, Norway; and Susanna Abrahmsén Alami, AstraZeneca, Sweden
Attendees of the educational workshop will gain knowledge of the basics and further application of molecular and pharmaceutical imaging. Talented speakers and lively discussions will direct the participants on the selection, utilization, and evaluation of the different methodologies.

• Probing ER Matrix Dissolution Processes by NMR Microimaging, Susanna Abrahmsén Alami, AstraZeneca, Sweden
• Hunting the Drug—Spatially Resolved Thermal Analysis of Dosage Forms, Duncan Craig, University of East Anglia, U.K.
• Novel Applications of In Vitro Imaging Techniques in Solid Dosage Forms Development and Manufacturing, Lasse Heikkinen, University of Kuopio, Finland
• Development of Biomarkers and Imaging Agents, Ole Hjelstuen, University of Tromsø and GE Healthcare, Norway
• Therapeutics: Shorter Time to Patient Benefit by Use of Imaging—Pharmacokinetics and Efficacy by PET, Bengt Langstrom, Uppsala University and GE Healthcare, Sweden
• Paradigm Shift in the Regulatory Environment for Rapid Human Proof-of-Concept—Microdosing, Lars Martiny, Risø Laboratories, Denmark
• Molecular Imaging in Drug Development, Alan Perkins, University of Nottingham, U.K.
• Surface Analysis and Chemical Imaging of Pharmaceutical Solids, Mark Nicholas, AstraZeneca R&D, Sweden
• Dynamic 3-D Image Analysis in Characterisation of Powder Functionality, Niklas Sandler, University of Helsinki, Finland
• Micro-imaging in Drug Development; Micro-CT, Micro-MR, Micro-PET, Micro-SPECT, and Combinations; The Role of Micro-imaging in Lead Compound Selection, Alfons Verbruggen, Katholieke Universiteit Leuven, Belgium
• In Depth Insights—Tomographic Imaging Using Terahertz and Magnetic Resonance Techniques for Dosage Form and Process Development, Axel Zeitler, Cambridge University, U.K.

Educational Workshop 3: In Vivo Dissolution - Is It a Reality? Can It Be Correlated to In Vitro or In Silico DISSOLUTION?; chaired by Daniel Bar-Shalom, IPC International Operations A/S, Denmark; and Anette Müllertz, Bioneer:FARMA, Denmark
Attendees will gain an improved understanding of the intra-luminal processes in the gastro-intestinal tract. Also, attendees will receive an overview of the state of the art technologies to achieve in vivo in vitro correlation.

• Composition of Human Gastrointestinal Fluids, Patrick Augustijns, Catholic University of Leuven, Belgium
• Whole Body Physiologically-based Pharmacokinetic Models: Their Use in Clinical Drug Development, Corina Becker, Bayer Technology Services, Germany
• Application of Modeling and Simulations in Drug Development, John Crison, Simulation Plus, U.S.A.
• New Trends in Dissolution Automation, Gilles Devidts, SOTAX, Switzerland
• Biorelevant Release Testing of ER Products, Nicoletta Fotaki, University of Bath, U.K.
• Dissolution Media Simulating the Gastrointestinal Fluids, Ekarat Jantratid, University of Frankfurt, Germany
• A New USP IV 4 System Design, Manfred Koller, Erweka, Germany
• Simulating Solubilisation and Absorption During Digestion in the GI Tract, Anette Müllertz, University of Copenhagen, Denmark
• The USP IV Apparatus in Biorelevant Release Testing, Christos Reppas, University of Athens, Greece
• Application of Quality by Design: A Regulatory Perspective on In Vitro Models, Arzu Selen, FDA, U.S.A.
• Simulating Gut Motility: Impact on Dissolution Outcomes, Werner Weitschies, University of Greifswald, Germany
• In Vivo and In Vitro Correlation: The Physiological Challenges, Clive Wilson, Strathclyde Institute of Pharmacy and Biomedical Sciences, U.K.
• In Vitro Assessment of Simultaneous Dissolution and Permeation by Use of Caco-2 Cell Culture Model, Shinji Yamashita, Setsunan University, Japan
• The TIM Model for Simulating Digestion--New Aspects, Evelijn Zeijdner, TNO, The Netherlands

Educational Workshop 4: Micro and Nano Encapsulation; chaired by Christophe Barbe, Ceramisphere Pty Ltd, Australia; and Teresa Virgallito, Microtek Laboratories, U.S.A.
Attendees will gain an in-depth learning of various forms of controlled release used in Consumer & Diversified Products' (C&DP) areas. An understanding of varying types of analysis and processes that are utilized in industry and academia will be explored. Additionally, attendees will gain an understanding of numerous drying processes that are used to make CR products, develop an understanding on how to formulate products, and an understanding of how to evaluate products using multiple types of analytical techniques.

• Micro- and Nano-encapsulation Using Inorganic Matrices for Consumer and Diversified Products, Christophe Barbe, CeramiSphere Pty Ltd, Australia
• Particle Size Measurement from Nanometres to Centimetres and Rods to Platelets and Those Undefinable Things In-between, Paul Bowen, Ecole Polytechnique Fédérale de Lausanne, Switzerland
• Rapid Method for Evaluating Micro Encapsulation Efficiency, Robert Djernaes, GEA Niro, Denmark
• Fluidization Dynamics and Related Parameter Considerations for Wurster Fluid Bed Micro-encapsulation Processes, Charles Frey, Coating Place Inc., U.S.A.
• Comparison of Dissolution Methods for the Characterization of Bioceramic Granules Used as Ibuprofen Carrier, Samir Haddouchi, SPS Pharma Services, France
• Micro- and Nanoencapsulation Using Spray Drying Technology, Irv Jacobs, Jacobs Controlled Release Technology Consulting, U.S.A.
• Options in Single and Multilayered Particulate Processing, Brian Jensen, Vector Corporation, U.S.A.
• Nanoparticles: Preparation and Applications, Joerg Kreuter, University of Frankfurt, Germany
• Food Products and Ingredients from Extrusion Processing: Principle and Examples, John Mitchell, University of Nottingham, U.K.
• Liposomal Encapsulation of Biomolecules for the Food Industry, Mike Patane, Protech Research Pty Ltd, Australia
• Micro- and Nano-encapsulation for Veterinary Applications, Michael Rathbone, Griffith University, Australia
• Controlled Release of Active Ingredients Encapsulated in Emulsions and Gels, Gerard Trouvé, Seppic, France
• Coacervative Micro-encapsulation, Ronald Versic, Ronald T. Dodge Company, U.S.A.
• Phase Change Material Encapsulation for the Medical Device Industry, Teresa Virgallito, Microtek Laboratories, U.S.A.
• Microencapsulation for Consumer Care and Industrial Applications, Fanwen Zeng, The Dow Chemical Company, U.S.A.